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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM639880
Substrate
n/a
Meas. Tech.
hEP4 cAMP Assay
IC50
1.000±n/a nM
Citation
 Boss, C; Corminboeuf, O; Fretz, H; Lyothier, I; Pozzi, D; Richard-Bildstein, S; Siendt, H; Sifferlen, T Pyrimidine derivatives as PGE2 receptor modulators US Patent  US11839613 Publication Date 12/12/2023 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM639880
Synonyms:
3-Ethoxy-5-{6-[2-(3-methoxy-1-methyl-naphthalen-2-yl)-ethylamino]-pyrimidin-4-yl}- thiophene-2-carboxylic acid | US11839613, Example 1
Type:
Small organic molecule
Emp. Form.:
C25H25N3O4S
Mol. Mass.:
463.549
SMILES:
CCOc1cc(sc1C(O)=O)-c1cc(NCCc2c(C)c3ccccc3cc2OC)ncn1
Structure:
Search PDB for entries with ligand similarity: