Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM640357
Substrate
n/a
Ki
<100.0±n/a nM
Citation
 Thatcher, GR; Xiong, R; Zhao, J; Li, Y Pyridinone-based epigenetic modifiers and uses thereof US Patent  US11840533 Publication Date 12/12/2023 
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM640357
Synonyms:
N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- pyrrolo[2,3-c]pyridin-3-yl)- 1H-indazol-4- yl)methanesulfonamide | US11840533, Compound 30
Type:
Small organic molecule
Emp. Form.:
C23H20FN5O3S
Mol. Mass.:
465.5
SMILES:
Cn1cc(-c2cc(NS(C)(=O)=O)c3cnn(Cc4ccc(F)cc4)c3c2)c2ccnc(O)c12
Structure:
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