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Target
Activin receptor type-1 [147-509]
Ligand
BDBM640389
Substrate
n/a
Meas. Tech.
ALK2 HTRF Assay
IC50
<1±n/a nM
Citation
 Pan, J; Bai, Y; Wu, L; Yao, W Imidazopyridazine compounds and uses thereof US Patent  US11840546 Publication Date 12/12/2023 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM640389
Synonyms:
US11840546, Example 1
Type:
Small organic molecule
Emp. Form.:
C36H36N8O
Mol. Mass.:
596.724
SMILES:
CCn1cnc(c1)-c1ccc2c(ccnc2n1)-c1cnc2cc(c(C)nn12)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r|
Structure:
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