Reaction Details Report a problem with these data
Target
Activin receptor type-1 [147-509]
Ligand
BDBM640390
Substrate
n/a
Meas. Tech.
ALK2 HTRF Assay
IC50
<1±n/a nM
Citation
 Pan, J; Bai, Y; Wu, L; Yao, W Imidazopyridazine compounds and uses thereof US Patent  US11840546 Publication Date 12/12/2023 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM640390
Synonyms:
US11840546, Example 2
Type:
Small organic molecule
Emp. Form.:
C34H34N8
Mol. Mass.:
554.6874
SMILES:
CCn1cnc(c1)-c1ccc2c(ccnc2n1)-c1cnc2cc(c(C)nn12)-c1ccc(CN2CC3CCC2CC3)cc1 |(-6.36,6.78,;-4.85,6.46,;-4.37,4.99,;-2.91,4.52,;-2.91,2.98,;-4.37,2.5,;-5.28,3.75,;-4.85,1.04,;-3.82,-.11,;-4.3,-1.57,;-5.8,-1.89,;-6.28,-3.36,;-7.78,-3.68,;-8.82,-2.53,;-8.34,-1.07,;-6.83,-.75,;-6.36,.72,;-5.25,-4.5,;-5.57,-6.01,;-4.23,-6.78,;-3.09,-5.75,;-1.56,-5.91,;-.65,-4.66,;-1.28,-3.26,;-.37,-2.01,;-2.81,-3.09,;-3.72,-4.34,;.88,-4.82,;1.5,-6.23,;3.04,-6.39,;3.94,-5.15,;5.47,-5.31,;6.38,-4.06,;7.91,-4.22,;8.82,-2.98,;8.19,-1.57,;6.66,-1.41,;5.75,-2.65,;7.09,-3.42,;7.48,-1.94,;3.32,-3.74,;1.78,-3.58,)|
Structure:
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