Reaction Details Report a problem with these data
Target
Activin receptor type-1 [147-509]
Ligand
BDBM640391
Substrate
n/a
Meas. Tech.
ALK2 HTRF Assay
IC50
<1±n/a nM
Citation
 Pan, J; Bai, Y; Wu, L; Yao, W Imidazopyridazine compounds and uses thereof US Patent  US11840546 Publication Date 12/12/2023 
Target
Name:
Activin receptor type-1 [147-509]
Synonyms:
ACVR1 | ACVR1_HUMAN | ACVRLK2 | Activin receptor-like kinase 2 (ALK-2) (aa 147-509)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41331.39
Organism:
Homo sapiens (Human)
Description:
aa147-end
Residue:
363
Sequence:
RKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
  
Inhibitor
Name:
BDBM640391
Synonyms:
US11840546, Example 3
Type:
Small organic molecule
Emp. Form.:
C32H31N9
Mol. Mass.:
541.6488
SMILES:
Cc1cnn(n1)-c1ccc2c(ccnc2n1)-c1cnc2cc(c(C)nn12)-c1ccc(CN2CC3CCC2CC3)cc1 |(-4.85,6.62,;-4.37,5.15,;-2.91,4.68,;-2.91,3.14,;-4.37,2.66,;-5.28,3.91,;-4.85,1.2,;-3.82,.05,;-4.3,-1.41,;-5.8,-1.73,;-6.28,-3.2,;-7.78,-3.52,;-8.82,-2.37,;-8.34,-.91,;-6.83,-.59,;-6.36,.88,;-5.25,-4.34,;-5.57,-5.85,;-4.23,-6.62,;-3.09,-5.59,;-1.56,-5.75,;-.65,-4.5,;-1.28,-3.1,;-.37,-1.85,;-2.81,-2.93,;-3.72,-4.18,;.88,-4.66,;1.5,-6.07,;3.04,-6.23,;3.94,-4.99,;5.47,-5.15,;6.38,-3.9,;7.91,-4.06,;8.82,-2.82,;8.19,-1.41,;6.66,-1.25,;5.75,-2.49,;7.09,-3.26,;7.48,-1.78,;3.32,-3.58,;1.78,-3.42,)|
Structure:
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