Reaction Details Report a problem with these data
Target
NAD(+) hydrolase SARM1
Ligand
BDBM8726
Substrate
n/a
Meas. Tech.
n Vitro Biochemical Test of Inhibiting SARM1 Enzyme Activity Assay
IC50
>10000±n/a nM
Citation
 NIU, D; ZHU, Z; ZHAO, Y; LI, W SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF IN NEURODEGENERATIVE DISEASES US Patent  US20230414581 Publication Date 12/28/2023 
Target
Name:
NAD(+) hydrolase SARM1
Synonyms:
3.2.2.- | 3.2.2.6 | HsTIR | KIAA0524 | MyD88-5 | NAD(+) hydrolase SARM1 | NADP(+) hydrolase SARM1 | NADase SARM1 | SAM domain-containing protein 2 | SAMD2 | SAMD2 GN | SARM | SARM1 | SARM1_HUMAN | Sterile alpha and Armadillo repeat protein | Sterile alpha and TIR motif-containing protein 1 | Sterile alpha motif domain-containing protein 2 | Synonyms=KIAA0524 | Tir-1 homolog | hSARM1
Type:
PROTEIN
Mol. Mass.:
79387.31
Organism:
Homo sapiens
Description:
ChEMBL_119100
Residue:
724
Sequence:
MVLTLLLSAYKLCRFFAMSGPRPGAERLAVPGPDGGGGTGPWWAAGGRGPREVSPGAGTEVQDALERALPELQQALSALKQAGGARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALGNCALHGGQAVQRRMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVERSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQRLVPLLDSNRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTKSALAKRALRLLGEEVPRPILPSVPSWKEAEVQTWLQQIGFSKYCESFREQQVDGDLLLRLTEEELQTDLGMKSGITRKRFFRELTELKTFANYSTCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIHLGVHRARILTAAREMLHSPLPCTGGKPSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVMGARNFVLVLSPGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQVLPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRSSRDSSAGSDTSLEGAAPMGPT
  
Inhibitor
Name:
BDBM8726
Synonyms:
5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35
Type:
Small organic molecule
Emp. Form.:
C12H7Cl3O2
Mol. Mass.:
289.542
SMILES:
Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: