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Target
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3
Ligand
BDBM642760
Substrate
n/a
Meas. Tech.
Kinase Activity Assay
IC50
3.00±n/a nM
Citation
 Cheng, H; Xiong, W; Niu, W; Yu, B; Jiang, Y HETEROARYLQUINAZOLINE COMPOUNDS AS PROTEIN KINASE INHIBITORS US Patent  US20230416271 Publication Date 12/28/2023 
Target
Name:
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3
Synonyms:
CDK4/Cyclin D3
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1806445
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Component 2
Name:
G1/S-specific cyclin-D3
Synonyms:
CCND3 | CCND3_HUMAN
Type:
Enzyme
Mol. Mass.:
32521.90
Organism:
Homo sapiens (Human)
Description:
P30281
Residue:
292
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
  
Inhibitor
Name:
BDBM642760
Synonyms:
1-isopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-1H-[1,2,3] triazolo[4,5-h]quinazolin-8-amine | US20230416271, Compound II.14 | US20230416271, Compound II.25 | US20230416271, Compound II.37
Type:
Small organic molecule
Emp. Form.:
C17H23N7O2S
Mol. Mass.:
389.475
SMILES:
CC(C)n1nnc2ccc3cnc(NC4CCN(CC4)S(C)(=O)=O)nc3c12
Structure:
Search PDB for entries with ligand similarity: