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Target
Procathepsin L
Ligand
BDBM642843
Substrate
n/a
Meas. Tech.
Human Cathepsin L (CatL) Enzymatic Assay
IC50
0.800±n/a nM
Citation
 Fang, L; Wang, Y; Ma, T; Song, L; Huang, Z; Yang, J; Gu, S Cathepsin L inhibitors US Patent  US11858905 Publication Date 1/2/2024 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM642843
Synonyms:
US11858905, Compound 43
Type:
Small organic molecule
Emp. Form.:
C32H34N8O3
Mol. Mass.:
578.6642
SMILES:
CCNc1ccc(cn1)-c1ccc2nc(C[C@H](NC(=O)c3cc(nn3C3CC3)C3(C)CC3)C(=O)NC3(CC3)C#N)oc2c1 |r|
Structure:
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