Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM312058
Substrate
n/a
Meas. Tech.
procaspase-3 activation
EC50
>50000±n/a nM
Citation
 Hergenrother, PJ; Putt, KS; Peterson, QP; Fako, V Compounds and methods for the treatment of cancer US Patent  US10166229 Publication Date 1/1/2019 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM312058
Synonyms:
US10166229, Example 00028
Type:
Small organic molecule
Emp. Form.:
C15H22N4O
Mol. Mass.:
274.3614
SMILES:
C\C=N\NC(=O)CN1CCN(Cc2ccccc2)CC1
Structure:
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