Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM36370
Substrate
n/a
Meas. Tech.
procaspase-3 activation
EC50
>50000±n/a nM
Citation
 Hergenrother, PJ; Putt, KS; Peterson, QP; Fako, V Compounds and methods for the treatment of cancer US Patent  US10166229 Publication Date 1/1/2019 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM36370
Synonyms:
CID207112 | Piperazin-1-yl-acetic acid ethyl ester, 8 | US10166229, Example 00031
Type:
Small organic moelcule
Emp. Form.:
C8H16N2O2
Mol. Mass.:
172.2248
SMILES:
CCOC(=O)CN1CCNCC1
Structure:
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