Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM524526
Substrate
n/a
Meas. Tech.
A2B Filter Binding Assay
EC50
<10±n/a nM
Citation
 Wang, X; Han, H; McCammant, MS; Wu, L; Yao, W; Yu, Z; Zhao, L Fused pyrimidine derivatives as A2A/A2B inhibitors US Patent  US11873304 Publication Date 1/16/2024 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM524526
Synonyms:
US11168089, Ex. No. 2 | US11873304, Example 2
Type:
Small organic molecule
Emp. Form.:
C19H14N6
Mol. Mass.:
326.3547
SMILES:
Nc1nc(cc2nc(Cc3ccccc3)nn12)-c1cccc(c1)C#N
Structure:
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