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Target
GTPase KRas [G12D]
Ligand
BDBM647886
Substrate
n/a
Meas. Tech.
KRAS G12D LoEnz Biochemical Assay
IC50
0.090±n/a nM
Citation
 Landry, ML; Nilewski, C; Siu, M; Villemure, E; Wang, Y; Wei, B; Ashley, MA; Do, S; Gazzard, LJ; Green, SA AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF US Patent  US20240025919 Publication Date 1/25/2024 
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM647886
Synonyms:
US20240025919, Compound 118
Type:
Small organic molecule
Emp. Form.:
C32H36F5N7O3
Mol. Mass.:
661.6654
SMILES:
C[C@@H]1Oc2nc(c(F)c3nc(OCC4(CN5CCOCC5)CC4)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(N)c(F)c(C)c1C(F)(F)F |r|
Structure:
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