Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM648284
Substrate
n/a
Meas. Tech.
MIF Enzymatic Assay
IC50
174±n/a nM
Citation
 Fan, G; Fong, KC; Yang, H; Wang, J Compounds and their uses as MIF inhibitors US Patent  US11884682 Publication Date 1/30/2024 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM648284
Synonyms:
4-(2-(dimethylamino)ethoxy)-2- methoxy-N-(5-(thiophen-2-yl)-1,3,4- oxadiazol-2-yl)benzamide | US11884682, Compound 20
Type:
Small organic molecule
Emp. Form.:
C18H20N4O4S
Mol. Mass.:
388.441
SMILES:
COc1cc(OCCN(C)C)ccc1C(=O)Nc1nnc(o1)-c1cccs1
Structure:
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