Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [364-436]
Ligand
BDBM179640
Substrate
n/a
Meas. Tech.
FP Competitive Binding Assay (No.350)
Temperature
298.15±n/a K
Ki
53±2.70 nM
Comments
extracted
Citation
Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017
More Info.:
Target
Name:
Bromodomain-containing protein 2 [364-436]
Synonyms:
BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)(BD2) | Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
8615.14
Organism:
Homo sapiens (Human)
Description:
BD2 (364-436 aa) of P25440
Residue:
73
Sequence:
KHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVV
Inhibitor
Name:
BDBM179640
Synonyms:
US9675697, Cpd. No. 352
Type:
Small organic molecule
Emp. Form.:
C27H23N5O2
Mol. Mass.:
449.5038
SMILES:
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3cn(nc3C)-c3ccccc3)c21 |(-1.5,3.22,;-2.13,1.81,;-1.36,.48,;.18,.48,;.95,-.85,;.18,-2.19,;-1.36,-2.19,;-2.13,-.85,;-3.67,-.85,;-4.57,-2.1,;-4.18,-3.59,;-6.04,-1.62,;-6.04,-.08,;-4.57,.39,;-4.18,1.88,;1.21,-3.33,;2.62,-2.71,;4.03,-3.33,;5.27,-2.43,;5.11,-.9,;3.7,-.27,;3.31,1.22,;4.55,2.12,;4.08,3.59,;2.54,3.59,;2.06,2.12,;.57,1.72,;4.98,4.83,;6.51,4.67,;7.42,5.92,;6.79,7.33,;5.26,7.49,;4.35,6.24,;2.46,-1.17,)|