Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [364-436]
Ligand
BDBM179574
Substrate
n/a
Meas. Tech.
FP Competitive Binding Assay (No.350)
Temperature
298.1500±n/a K
Ki
4.50±n/a nM
Comments
extracted
Citation
 Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent  US9675697B2 Publication Date 6/13/2017 
Target
Name:
Bromodomain-containing protein 2 [364-436]
Synonyms:
Bromodomain-containing protein 2 Bromo 2 domain(BRD2 BD2) | Bromodomain-containing protein 2 (BRD2)(BD2) | BRD2_HUMAN | BRD2 | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
8615.14
Organism:
Human
Description:
BD2 (364-436 aa) of P25440
Residue:
73
Sequence:
KHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVV
  
Inhibitor
Name:
BDBM179574
Synonyms:
US9675697, Cpd. No. 212
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
625.34
SMILES:
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc(C(=O)NC4CCN(C5CCOCC5)CC4)[nH]c3C(C)C)c12
Structure:
Search PDB for entries with ligand similarity: