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Target
Cyclin-dependent kinase 4/6
Ligand
BDBM648821
Substrate
n/a
Meas. Tech.
CDK6/Cyclin D3 ADP-Glo Kinase Assay
IC50
<200±n/a nM
Citation
 VERNIER, W; NGUYEN, QN; REZAYEE, N; GOMEZ, L; ZHANG, C; MILLER, III, TF; MANBY, FR AZA-QUINAZOLINE COMPOUNDS AND METHODS OF USE US Patent  US20240034731 Publication Date 2/1/2024 
Target
Name:
Cyclin-dependent kinase 4/6
Synonyms:
CDK6/Cyclin D3 | Cyclin-dependent kinase 4/6
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Component 2
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM648821
Synonyms:
8-(1,1-difluoro-5-azaspiro[2.4]heptan-5-yl)-N-(1- (1-methylpiperidin-4-yl)-1H-pyrazol-4- yl)pyrido[3,4-d]pyrimidin-2-amine | US20240034731, Compound 20
Type:
Small organic molecule
Emp. Form.:
C22H26F2N8
Mol. Mass.:
440.4922
SMILES:
CN1CCC(CC1)n1cc(Nc2ncc3ccnc(N4CCC5(CC5(F)F)C4)c3n2)cn1
Structure:
Search PDB for entries with ligand similarity: