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Target
Programmed cell death 1 ligand 1
Ligand
BDBM649679
Substrate
n/a
Meas. Tech.
Affinity Test Between the Compounds of the Invention and hPD-L1 Protein
Kd
50±n/a nM
Citation
 XU, Y; ZHANG, H; ZHU, Q; DU, H; XIA, Y; YU, C; HUANG, S; LI, H; ZOU, Y NOVEL BIPHENYL DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF US Patent  US20240043392 Publication Date 2/8/2024 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM649679
Synonyms:
(4-((3′-(3-(4-(((1-carboxy-2-hydroxyethyl)amino)methyl)-1H-1,2,3-triazol-1-yl)propoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)methoxy)-5-chloro-2-methoxybenzyl)serine | US20240043392, Compound II-7
Type:
Small organic molecule
Emp. Form.:
C35H42ClN5O9
Mol. Mass.:
712.189
SMILES:
COc1cc(OCc2cccc(c2C)-c2cccc(OCCCn3cc(CNC(CO)C(O)=O)nn3)c2C)c(Cl)cc1CN[C@@H](CO)C(O)=O
Structure:
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