Reaction Details Report a problem with these data
Target
Toll-like receptor 2
Ligand
BDBM649705
Substrate
n/a
Meas. Tech.
LR2 Assays
IC50
600±n/a nM
Citation
 NATALA, SR; WRASIDLO, WJ; STOCKING, EM COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING US Patent  US20240043395 Publication Date 2/8/2024 
Target
Name:
Toll-like receptor 2
Synonyms:
TIL4 | TLR2 | TLR2_HUMAN | Toll-like receptor 2 | Toll-like receptor 2 (TLR2)
Type:
Protein
Mol. Mass.:
89837.58
Organism:
Homo sapiens (Human)
Description:
O60603
Residue:
784
Sequence:
MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
  
Inhibitor
Name:
BDBM649705
Synonyms:
3-fluoro-5-formyl-4-hydroxy- N-(5-(3-(pyrrolidin-1- yl)phenyl)thiazol-2- yl)benzamide | US20240043395, Compound 12
Type:
Small organic molecule
Emp. Form.:
C21H18FN3O3S
Mol. Mass.:
411.449
SMILES:
Oc1c(F)cc(cc1C=O)C(=O)Nc1ncc(s1)-c1cccc(c1)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: