Reaction Details Report a problem with these data
Target
Diacylglycerol kinase delta
Ligand
BDBM649792
Substrate
n/a
Meas. Tech.
Evaluation of DGKdelta Inhibitory Effect
IC50
10.00±n/a nM
Citation
 Watanabe, H; Kamikubo, T; Kamikawa, A; Washio, T; Seki, Y; Okuyama, K; Ikeda, O; Tomiyama, H; Iwai, Y; Nakamura, A; Miyasaka, K HETEROARYL CARBOXAMIDE COMPOUND US Patent  US20240043403 Publication Date 2/8/2024 
Target
Name:
Diacylglycerol kinase delta
Synonyms:
130 kDa diacylglycerol kinase | DAG kinase delta | DGK-delta | Diglyceride kinase delta
Type:
Protein
Mol. Mass.:
134541.20
Organism:
Human
Description:
Q16760
Residue:
1214
Sequence:
MAAAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVEA
  
Inhibitor
Name:
BDBM649792
Synonyms:
US20240043403, Example 122 | US20240043403, Example 29 | US20240043403, Example 90
Type:
Small organic molecule
Emp. Form.:
C28H28F4N8O2
Mol. Mass.:
584.5679
SMILES:
CNC[C@H]1CN(CCN1C)c1c(NC(=O)c2ccn(n2)-c2ccnnc2)ccc(Oc2ccccc2F)c1C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: