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Target
Transcription factor p65
Ligand
BDBM49381
Substrate
n/a
Meas. Tech.
cell-based NF-kB reporter assay
EC50
210±n/a nM
Citation
 Suto, MJ; Mathew, B; Cowell, R; Augelli-Szafran, CE 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases US Patent  US11905258 Publication Date 2/20/2024 
Target
Name:
Transcription factor p65
Synonyms:
Nfkb3 | Nuclear factor NF-kappa-B p65 subunit | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | Rela | TF65_MOUSE | Transcription factor p65
Type:
PROTEIN
Mol. Mass.:
60204.69
Organism:
Mus musculus
Description:
ChEMBL_101597
Residue:
549
Sequence:
MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
  
Inhibitor
Name:
BDBM49381
Synonyms:
(3-Methyl-pyridin-2-yl)-(4-pyridin-2-yl-thiazol-2-yl)-amine | (3-methyl-2-pyridyl)-[4-(2-pyridyl)thiazol-2-yl]amine | MLS000528306 | N-(3-methyl-2-pyridinyl)-4-(2-pyridinyl)-2-thiazolamine | N-(3-methylpyridin-2-yl)-4-pyridin-2-yl-1,3-thiazol-2-amine | SMR000120881 | US11905258, Example 2-22819 | cid_972880
Type:
Small organic molecule
Emp. Form.:
C14H12N4S
Mol. Mass.:
268.337
SMILES:
Cc1cccnc1Nc1nc(cs1)-c1ccccn1
Structure:
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