Reaction Details
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Report a problem with these dataTarget
Plasminogen
Ligand
BDBM652422
Substrate
n/a
Meas. Tech.
Determination of Related Protease Inhibition
IC50
3.00±n/a nM
Citation
CHILDS, ML; DAVIE, RL; EDWARDS, HJ; EVANS, DM; GREVES, WJ; HODGSON, ST; MAZZACANI, A; NORTH, CL; OBARA, AS; ROE, MB; ROOKER, DP; STOCKS, MJ; BIRCH, LM; PICHOWICZ, M; PITTAWAY, R; SMITH, AJ; THROUP, AE; WRIGGLESWORTH, JW; YANG, X; CLARK, DE ENZYME INHIBITORS US Patent US20240059691 Publication Date 2/22/2024 More Info.:
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Inhibitor
Name:
BDBM652422
Synonyms:
5-N-({4-[(1-methylpiperidin-4-yl)oxy]phenyl}methyl)isoquinoline-1,5-diamine | US20240059691, Example 1002
Type:
Small organic molecule
Emp. Form.:
C22H26N4O
Mol. Mass.:
362.468
SMILES:
CN1CCC(CC1)Oc1ccc(CNc2cccc3c(N)nccc23)cc1
Structure:
