Reaction Details Report a problem with these data
Target
Caspase-6
Ligand
BDBM10335
Substrate
Caspase-6 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
IC50
>5000±n/a nM
Citation
 Chu, W; Zhang, J; Zeng, C; Rothfuss, J; Tu, Z; Chu, Y; Reichert, DE; Welch, MJ; Mach, RH N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J Med Chem 48:7637-47 (2005) [PubMed]  Article 
Target
Name:
Caspase-6
Synonyms:
Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2
Type:
Enzyme
Mol. Mass.:
33312.62
Organism:
Homo sapiens (Human)
Description:
P55212
Residue:
293
Sequence:
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
  
Inhibitor
Name:
BDBM10335
Synonyms:
(S)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1H-indole-2,3-dione | 1-[(6-fluoropyridin-3-yl)methyl]-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | Pyrrolidine Isatin Analogue 11g
Type:
Small organic molecule
Emp. Form.:
C25H22FN3O5S
Mol. Mass.:
495.523
SMILES:
Fc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccccc2)cn1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-6 Fluorogenic Substrate
Synonyms:
Ac-VEID-AMC
Type:
n/a
Mol. Mass.:
1560.92
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
16
Sequence:
ACVALGLILEASPAMC