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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM313604
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity Determination
IC50
60.0±n/a nM
Citation
 Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Lou, Y; Nishiguchi, GA; Ramurthy, S; Rico, AC; Rauniyar, V; Sendzik, M; Subramanian, S; Setti, LQ; Taft, BR; Tanner, HR; Wan, L Compounds and compositions as RAF kinase inhibitors US Patent  US10167279 Publication Date 1/1/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM313604
Synonyms:
5-chloro-N-(3-(6- ethoxy-5-(tetrahydro- 2H-pyran-4-yl) pyridazin-3-yl)-4- methylphenyl)-4- (trifluoromethyl) picolinamide | US10167279, Example 228
Type:
Small organic molecule
Emp. Form.:
C25H24ClF3N4O3
Mol. Mass.:
520.931
SMILES:
CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2cc(c(Cl)cn2)C(F)(F)F)ccc1C
Structure:
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