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Target
Cyclin-dependent kinase 9
Ligand
BDBM316177
Substrate
n/a
Meas. Tech.
Fluorescent Polarization Assay
IC50
<1000±n/a nM
Citation
 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Örfi, L; Kéri, G 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity US Patent  US9617225 Publication Date 4/11/2017 
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
  
Inhibitor
Name:
BDBM316177
Synonyms:
N1-(6-(2-methoxyphenyl)pyrimidin-4-yl)- N4,N4-dimethylbenzene-1,4-diamine | US10294218, Example 5 | US9617225, Example 5
Type:
Small organic molecule
Emp. Form.:
C19H20N4O
Mol. Mass.:
320.3883
SMILES:
COc1ccccc1-c1cc(Nc2ccc(cc2)N(C)C)ncn1
Structure:
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