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Target
Cyclin-dependent kinase 9
Ligand
BDBM316211
Substrate
n/a
Meas. Tech.
Fluorescent Polarization Assay
IC50
<100±n/a nM
Citation
 Lori, F; Chafouleas, J; De Forni, D; Solinas, A; Varga, Z; Greff, Z; Örfi, L; Kéri, G 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity US Patent  US9617225 Publication Date 4/11/2017 
Target
Name:
Cyclin-dependent kinase 9
Synonyms:
C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
42789.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
372
Sequence:
MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFERVF
  
Inhibitor
Name:
BDBM316211
Synonyms:
N-(3-((1H-benzo[d]imidazol-1-yl)methyl)-4-ethoxyphenyl)-6-(2-methoxyphenyl)pyrimidin-4-amine | US10294218, Example 39 | US9617225, Example 39
Type:
Small organic molecule
Emp. Form.:
C27H25N5O2
Mol. Mass.:
451.5197
SMILES:
CCOc1ccc(Nc2cc(ncn2)-c2ccccc2OC)cc1Cn1cnc2ccccc12
Structure:
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