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Target
B1 bradykinin receptor
Ligand
BDBM614644
Substrate
n/a
Meas. Tech.
Calcium Flux Assays (hB1 IC50 free)
IC50
8.10±n/a nM
Citation
 BAEURLE, S; DAVENPORT, A; STIMSON, C; NAGEL, J; SCHMIDT, N; ROTGERI, A; GROETICKE, I; RAUSCH, A; KLAR, J; DYRKS, T CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR US Patent  US20230271931 Publication Date 8/31/2023 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM614644
Synonyms:
US20230271931, Example 2 | US20230271931, Example 96
Type:
Small organic molecule
Emp. Form.:
C26H19F7N2O3
Mol. Mass.:
540.4295
SMILES:
CCC(F)(F)c1ccc(cn1)-c1c(F)cc(NC(=O)C2(CC2)c2ccc(cc2F)C(F)(F)F)cc1C(O)=O
Structure:
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