Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM614769
Substrate
n/a
Meas. Tech.
Calcium Flux Assays (hB1 IC50 free)
IC50
11.0±n/a nM
Citation
 BAEURLE, S; DAVENPORT, A; STIMSON, C; NAGEL, J; SCHMIDT, N; ROTGERI, A; GROETICKE, I; RAUSCH, A; KLAR, J; DYRKS, T CARBOXYLIC ACID AROMATIC AMIDES AS ANTAGONISTS OF BRADYKININ B1 RECEPTOR US Patent  US20230271931 Publication Date 8/31/2023 
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Homo sapiens (Human)
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
  
Inhibitor
Name:
BDBM614769
Synonyms:
2-[1- (Cyclopropyl- methyl)- 1H-pyrazol- 4-yl]-3-fluoro-5- [({1-[2-fluoro-4- (trifluoromethoxy) phenyl]cyclo- propyl}carbonyl) | US20230271931, Example 127
Type:
Small organic molecule
Emp. Form.:
C25H20F5N3O4
Mol. Mass.:
521.436
SMILES:
OC(=O)c1cc(NC(=O)C2(CC2)c2ccc(OC(F)(F)F)cc2F)cc(F)c1-c1cnn(CC2CC2)c1
Structure:
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