Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM318943
Substrate
n/a
Meas. Tech.
HEK-URAT1 assay
IC50
3440±n/a nM
Citation
 Endo, T; Kobayashi, K; Tanaka, H; Saito, D; Hirano, M; Endou, H; Anzai, N URAT1 inhibitor US Patent  US10173990 Publication Date 1/8/2019 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM318943
Synonyms:
2-[[5-(4-Cyanophenyl)quinolin-6-yl]thio]-2-methylpropanoic acid | US10173990, Example 15
Type:
Small organic molecule
Emp. Form.:
C20H16N2O2S
Mol. Mass.:
348.418
SMILES:
CC(C)(Sc1ccc2ncccc2c1-c1ccc(cc1)[N+]#[C-])C(O)=O
Structure:
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