Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM318953
Substrate
n/a
Meas. Tech.
HEK-URAT1 assay
IC50
2433±n/a nM
Citation
 Endo, T; Kobayashi, K; Tanaka, H; Saito, D; Hirano, M; Endou, H; Anzai, N URAT1 inhibitor US Patent  US10173990 Publication Date 1/8/2019 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM318953
Synonyms:
1-[[7-(4-Cyanophenyl)-3-methylbenzo[d]isothiazol-6-yl]thio]cyclobutan-1-carb oxylic acid | US10173990, Example 112
Type:
Small organic molecule
Emp. Form.:
C20H16N2O2S2
Mol. Mass.:
380.483
SMILES:
Cc1nsc2c(c(SC3(CCC3)C(O)=O)ccc12)-c1ccc(cc1)C#N
Structure:
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