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Target
Endothelial lipase
Ligand
BDBM319094
Substrate
n/a
Meas. Tech.
Biological Activity
IC50
1.000±n/a nM
Citation
 Johnson, JA; Pi, Z; Qiao, JX; Kim, S; Wang, TC; Jiang, J; Finlay, H; Lloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent  US10173991 Publication Date 1/8/2019 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM319094
Synonyms:
N-[(cyclopropyl- carbamoyl) methyl]-2-{5- fluoro-6-[3-(1H- pyrazol-1-yl) phenyl]-1,3- benzothiazol- 2-yl}-2-(3,3,3- trifluoropropane- sulfonyl) acetamide | US10173991, Example 137
Type:
Small organic molecule
Emp. Form.:
C26H23F4N5O4S2
Mol. Mass.:
609.616
SMILES:
Fc1cc2nc(sc2cc1-c1cccc(c1)-n1cccn1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F
Structure:
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