Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM319205
Substrate
n/a
Meas. Tech.
Biological Activity
IC50
1.000±n/a nM
Citation
 Johnson, JA; Pi, Z; Qiao, JX; Kim, S; Wang, TC; Jiang, J; Finlay, H; Lloyd, J Sulfone amide linked benzothiazole inhibitors of endothelial lipase US Patent  US10173991 Publication Date 1/8/2019 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Homo sapiens (Human)
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM319205
Synonyms:
N-[(cyclopropyl- carbamoyl) methyl]-2-[5- fluoro-6-(2- methyl-1,3- benzothiazol-5- yl)-1,3- benzothiazol-2- yl]-2- methanesulfonyl- acetamide | US10173991, Example 248
Type:
Small organic molecule
Emp. Form.:
C23H21FN4O4S3
Mol. Mass.:
532.631
SMILES:
Cc1nc2cc(ccc2s1)-c1cc2sc(nc2cc1F)C(C(=O)NCC(=O)NC1CC1)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: