Target

Ligand

Substrate

Meas. Tech.

Carbonic Anhydrase Enzyme Inhibition Assay

Ki

37±n/a nM

Citation

 Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:3677-87 (2000) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

Interstitial collagenase

Synonyms:

CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)

Type:

Enzyme

Mol. Mass.:

54010.26

Organism:

Homo sapiens (Human)

Description:

P03956

Residue:

469

Sequence:

MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM11362

Synonyms:

2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,4-nonafluorobutane)sulfonamido}-N-hydroxypropanamide | Hydroxamate 43 | hydroxamate deriv. B4

Type:

Small organic molecule

Emp. Form.:

C14H12ClF9N2O4S

Mol. Mass.:

510.76

SMILES:

CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(=O)NO

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

BDBM11446

Synonyms:

AcProLeuGly-S-LeuLeuGlyOEt | MMP Thioester Substrate

Type:

n/a

Emp. Form.:

n/a

Mol. Mass.:

n/a

SMILES:

n/a

Structure: