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Target
NEDD8-conjugating enzyme UBE2F
Ligand
BDBM320969
Substrate
n/a
Meas. Tech.
Nedd8 Conjugation Inhibitory Activity
IC50
<3.00±n/a nM
Citation
 Mizutani, T; Yoshimura, C; Kondo, H; Kitade, M; Ohkubo, S Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof US Patent  US10174040 Publication Date 1/8/2019 
Target
Name:
NEDD8-conjugating enzyme UBE2F
Synonyms:
NCE2 | NEDD8 carrier protein UBE2F | NEDD8 protein ligase UBE2F | NEDD8-conjugating enzyme 2 | RING-type E3 NEDD8 transferase UBE2F | UBE2F | UBE2F_HUMAN | Ubiquitin-conjugating enzyme E2 F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21077.76
Organism:
Homo sapiens (Human)
Description:
Q969M7
Residue:
185
Sequence:
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR
  
Inhibitor
Name:
BDBM320969
Synonyms:
4-Amino-5-[2-(4-amino-2,6-difluoro-phenyl)ethynyl]-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(sulfamoylamino)methyl]tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine | US10174040, Example 24 | US9963456, Example 24
Type:
Small organic molecule
Emp. Form.:
C19H19F2N7O5S
Mol. Mass.:
495.46
SMILES:
Nc1cc(F)c(C#Cc2cn([C@@H]3O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]3O)c3ncnc(N)c23)c(F)c1
Structure:
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