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Target
NEDD8-conjugating enzyme UBE2F
Ligand
BDBM321049
Substrate
n/a
Meas. Tech.
Nedd8 Conjugation Inhibitory Activity
IC50
<3.00±n/a nM
Citation
 Mizutani, T; Yoshimura, C; Kondo, H; Kitade, M; Ohkubo, S Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof US Patent  US10174040 Publication Date 1/8/2019 
Target
Name:
NEDD8-conjugating enzyme UBE2F
Synonyms:
NCE2 | NEDD8 carrier protein UBE2F | NEDD8 protein ligase UBE2F | NEDD8-conjugating enzyme 2 | RING-type E3 NEDD8 transferase UBE2F | UBE2F | UBE2F_HUMAN | Ubiquitin-conjugating enzyme E2 F
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21077.76
Organism:
Homo sapiens (Human)
Description:
Q969M7
Residue:
185
Sequence:
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR
  
Inhibitor
Name:
BDBM321049
Synonyms:
US10174040, Example 132 | [(2R,3S,4R,5R)-5-[4-Amino-5-[2-(2,6-difluorophenyl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl sulfamate
Type:
Small organic molecule
Emp. Form.:
C19H17F2N5O6S
Mol. Mass.:
481.43
SMILES:
Nc1ncnc2n(cc(C#Cc3c(F)cccc3F)c12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O |$_AV:;4;3;2;1;7a;7;6;5;1;2;1;6;;5;4;3;2;;4a;5;1;2;1;;;;;;3;;4;$|
Structure:
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