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Target
Tyrosine-protein kinase SYK
Ligand
BDBM189858
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
5821±0.0 nM
Comments
extracted
Citation
 Miller, TA; Petrocchi, A; Romeo, ET; Vitharana, D; Kattar, SD; Northrup, AB; Altman, MD; Anthony, NJ Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors US Patent  US9670196 Publication Date 6/6/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM189858
Synonyms:
US9670196, 1.3 1,1,1-trifluoro-2-{5-[3- methyl-5-(thieno[3,2- d]pyrimidin-4- ylamino)phenyl]-1,3- thiazol-2-yl}propan-2-ol
Type:
Small organic molecule
Emp. Form.:
C19H15F3N4OS2
Mol. Mass.:
436.474
SMILES:
Cc1cc(Nc2ncnc3ccsc23)cc(c1)-c1cnc(s1)[C@](C)(O)C(F)(F)F |r|
Structure:
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