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Target
Tyrosine-protein kinase SYK
Ligand
BDBM189869
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence (HTRF) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
1.171±0.0 nM
Comments
extracted
Citation
 Miller, TA; Petrocchi, A; Romeo, ET; Vitharana, D; Kattar, SD; Northrup, AB; Altman, MD; Anthony, NJ Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors US Patent  US9670196 Publication Date 6/6/2017 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM189869
Synonyms:
US9670196, 2.5 (R or S)-4-(1-hydroxy-1-{5- [3-methyl-5- ([1,2,4]triazolo[1,5- a]pyridin-2- ylamino)phenyl]-1,3- thiazol-2-yl}ethyl)benzoic acid | US9670196, 2.6 (R or S)-4-(1-hydroxy-1-{5- [3-methyl-5- ([1,2,4]triazolo[1,5- a]pyridin-2- ylamino)phenyl]-1,3- thiazol-2-yl}ethyl)benzoic acid
Type:
Small organic molecule
Emp. Form.:
C25H21N5O3S
Mol. Mass.:
471.531
SMILES:
Cc1cc(Nc2nc3ccccn3n2)cc(c1)-c1cnc(s1)C(C)(O)c1ccc(cc1)C(O)=O
Structure:
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