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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM321312
Substrate
n/a
Meas. Tech.
In Vitro Functional Activity (Agonism) on Human S1P1 Receptors (Method B)
EC50
<3162±n/a nM
Citation
 Stoit, A; Iwema Bakker, WI; Coolen, HK; van Dongen, MJ; Leflemme, NJ; Hobson, A Spiro-cyclic amine derivatives as S1P modulators US Patent  US10179791 Publication Date 1/15/2019 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM321312
Synonyms:
US10179791, Compound 128 | US10807991, Compound 128
Type:
Small organic molecule
Emp. Form.:
C23H25Cl2NO4
Mol. Mass.:
450.355
SMILES:
OC(=O)CCCN1CCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)CC1
Structure:
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