Reaction Details Report a problem with these data
Target
Chromatin remodeling regulator CECR2 [424-538]
Ligand
BDBM321455
Substrate
n/a
Meas. Tech.
IC50 Measurements for Inhibitors Using TAF1-BD2 TR-FRET Binding Assay
IC50
2000±n/a nM
Citation
 Albrecht, BK; Bellon, SF; Burdick, DJ; Cote, A; Crawford, T; Dakin, LA; Hsiao-Wei Tsui, V; Hewitt, MC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM; Wang, S Therapeutic compounds and uses thereof US Patent  US10183009 Publication Date 1/22/2019 
Target
Name:
Chromatin remodeling regulator CECR2 [424-538]
Synonyms:
CECR2 | CECR2 (aa 424-538) | CECR2_HUMAN | Cat eye syndrome critical region protein 2 [424-538] | KIAA1740
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13747.10
Organism:
Homo sapiens (Human)
Description:
Q9BXF3[424-538]
Residue:
115
Sequence:
MREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKH
  
Inhibitor
Name:
BDBM321455
Synonyms:
4-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl]-2-chloro-N,N-dimethyl-benzamide | US10183009, Example 43
Type:
Small organic molecule
Emp. Form.:
C20H20ClN3O2
Mol. Mass.:
369.845
SMILES:
C\C=C\Cn1cc(-c2ccc(C(=O)N(C)C)c(Cl)c2)c2cc[nH]c2c1=O
Structure:
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