Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM143749
Substrate
n/a
Meas. Tech.
Human Orexin 1 Receptor Ca2+ Mobilization Assay
Ki
27.0±n/a nM
Citation
 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US10183953 Publication Date 1/22/2019 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM143749
Synonyms:
US10183953, Example 10 | US8969352, 10 | US9611277, Example 10 | US9845333, 10
Type:
Small organic molecule
Emp. Form.:
C24H22F3N3O3
Mol. Mass.:
457.445
SMILES:
CCOc1ccc2cccnc2c1C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2 |TLB:20:19:15.16:32,13:15:19.18:32|
Structure:
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