Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 9
Ligand
BDBM11464
Substrate
BDBM11057
Meas. Tech.
Dipeptidyl Peptidase Inhibition Assay
IC50
1600±n/a nM
Citation
Xu, J; Wei, L; Mathvink, R; He, J; Park, YJ; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Wu, JK; Thornberry, NA; Weber, AE Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 15:2533-6 (2005) [PubMed] Article
More Info.:
Target
Name:
Dipeptidyl peptidase 9
Synonyms:
DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9
Type:
Enzyme
Mol. Mass.:
98260.70
Organism:
Homo sapiens (Human)
Description:
Q86TI2
Residue:
863
Sequence:
MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL
Inhibitor
Name:
BDBM11464
Synonyms:
(2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)pentan-1-one | BMCL15687 Compound 4 | CHEMBL98408 | P32-98 | thiazolidide 2
Type:
Small organic molecule
Emp. Form.:
C9H18N2OS
Mol. Mass.:
202.317
SMILES:
CC[C@H](C)[C@H](N)C(=O)N1CCSC1 |r|
Substrate
Name:
BDBM11057
Synonyms:
1-(2-aminoacetyl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)pyrrolidine-2-carboxamide hydrobromide | Gly-Pro-7-amido-4-methylcoumarin hydrobromide | Gly-Pro-7-amidomethylcoumarin | Gly-Pro-AMC
Type:
Small organic molecule
Emp. Form.:
C17H19N3O4
Mol. Mass.:
329.3505
SMILES:
Cc1cc(=O)oc2cc(NC(=O)C3CCCN3C(=O)CN)ccc12