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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM330392
Substrate
n/a
Meas. Tech.
Cyp21 Assay
IC50
10000±n/a nM
Citation
 Blass, BE; Abou-Gharbia, MA; Childers, WE; Iyer, P; Boruwa, J Cytochrome P450 inhibitors and their method of use US Patent  US9725436 Publication Date 8/8/2017 
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
CP17A_BOVIN | CYP17 | CYP17A1 | Cytochrome P450 21 (CYP21) | Cytochrome P450-C17 (CYP17A1)
Type:
Protein
Mol. Mass.:
57256.42
Organism:
Bos taurus (Bovine)
Description:
P05185
Residue:
509
Sequence:
MWLLLAVFLLTLAYLFWPKTKHSGAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAHWQLHRKLALNAFALFKDGNLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRNELLNEILEKCQENFSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREVLRIRPVAPTLIPHKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIPDDGKLPSLEGHASLVLQIKPFKVKIEVRQAWKEAQAEGSTP
  
Inhibitor
Name:
BDBM330392
Synonyms:
US9725436, Entry 11
Type:
Small organic molecule
Emp. Form.:
C23H25FN4O2S
Mol. Mass.:
440.534
SMILES:
CS(=O)(=O)N1CCN(CC1)c1ccc(\C=C\c2cc(F)cc(Cn3ccnc3)c2)cc1
Structure:
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