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Target
Cholesterol side-chain cleavage enzyme, mitochondrial
Ligand
BDBM330396
Substrate
n/a
Meas. Tech.
Cyp11 Assay
IC50
17.0±n/a nM
Citation
 Blass, BE; Abou-Gharbia, MA; Childers, WE; Iyer, P; Boruwa, J Cytochrome P450 inhibitors and their method of use US Patent  US9725436 Publication Date 8/8/2017 
Target
Name:
Cholesterol side-chain cleavage enzyme, mitochondrial
Synonyms:
CP11A_BOVIN | CYP11A1 | CYPXIA1 | Cholesterol desmolase | Cholesterol side-chain cleavage enzyme, mitochondrial | Cytochrome P450 11A1 | Cytochrome P450 11A1 (CYP11A1) | P450(scc)
Type:
Protein
Mol. Mass.:
60346.75
Organism:
Bos taurus (Bovine)
Description:
P00189
Residue:
520
Sequence:
MLARGLPLRSALVKACPPILSTVGEGWGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFNQDPPQA
  
Inhibitor
Name:
BDBM330396
Synonyms:
US9725436, Entry 15
Type:
Small organic molecule
Emp. Form.:
C26H28FN5O
Mol. Mass.:
445.5318
SMILES:
Fc1cc(Cn2ccnc2)cc(\C=C\c2ccc(cc2)N2CCN(CC2)C2=NCCCO2)c1 |t:29|
Structure:
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