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Target
Carbonic anhydrase 2
Ligand
BDBM12414
Substrate
BDBM11402
Meas. Tech.
Competitive Displacement Binding Assay
pH
7±n/a
Temperature
298.15±n/a K
Kd
660±n/a nM
Citation
 Jude, KM; Banerjee, AL; Haldar, MK; Manokaran, S; Roy, B; Mallik, S; Srivastava, DK; Christianson, DW Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity. J Am Chem Soc 128:3011-8 (2006) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM12414
Synonyms:
CHEMBL27601 | benzenesulfonamide | hCA inhibitor, 6
Type:
Small organic molecule
Emp. Form.:
C6H7NO2S
Mol. Mass.:
157.19
SMILES:
NS(=O)(=O)c1ccccc1
Structure:
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Substrate
Name:
BDBM11402
Synonyms:
5-(dimethylamino)naphthalene-1-sulfonamide | dansylamide
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2S
Mol. Mass.:
250.317
SMILES:
CN(C)c1cccc2c(cccc12)S(N)(=O)=O
Structure:
Search PDB for entries with ligand similarity: