Reaction Details Report a problem with these data
Target
Proteasome subunit alpha type-6
Ligand
BDBM65511
Substrate
n/a
Meas. Tech.
Proteasome Activity Assay
pH
7.5±n/a
Temperature
310.15±n/a K
EC50
8900±0.0 nM
Comments
extracted
Citation
 Jones, CL; Njomen, E; Sjögren, B; Dexheimer, TS; Tepe, JJ Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins. ACS Chem Biol 12:2240-2247 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit alpha type-6
Synonyms:
27 kDa prosomal protein | Macropain iota chain | Multicatalytic endopeptidase complex iota chain | PROS-27 | PROS27 | PSA6_HUMAN | PSMA6 | Proteasome iota chain | p27K
Type:
PROTEIN
Mol. Mass.:
27399.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
246
Sequence:
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
  
Inhibitor
Name:
BDBM65511
Synonyms:
CPZ analog, 5
Type:
Small organic molecule
Emp. Form.:
C20H23ClN2OS
Mol. Mass.:
374.927
SMILES:
Clc1ccc2Sc3ccccc3N(CCCCN3CCOCC3)c2c1
Structure:
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