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Target
Glycine receptor subunit alpha-1
Ligand
BDBM199088
Substrate
n/a
Meas. Tech.
Electrophysical Characterization Assay
EC50
0.0012±0.0004 nM
Citation
 Leuwer, M; O Neill, P; Berry, N; Pidathala, C Pharmacologically active compounds US Patent  US9676786 Publication Date 6/13/2017 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52635.39
Organism:
Homo sapiens (Human)
Description:
P23415
Residue:
457
Sequence:
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
  
Inhibitor
Name:
BDBM199088
Synonyms:
US9676786, example 6
Type:
Small organic molecule
Emp. Form.:
C18H28N2O2
Mol. Mass.:
304.4271
SMILES:
CC(C)c1cc(cc(C(C)C)c1O)C(=O)N1CCN(C)CC1
Structure:
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