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Target
Isoform Beta of cGMP-dependent protein kinase 1 [5-676,G306E]
Ligand
BDBM65501
Substrate
n/a
Meas. Tech.
Microfluidic Mobility-Shift Assay
pH
7±n/a
EC50
249±17 nM
Comments
extracted
Citation
 Campbell, JC; Henning, P; Franz, E; Sankaran, B; Herberg, FW; Kim, C Structural Basis of Analog Specificity in PKG I and II. ACS Chem Biol 12:2388-2398 (2017) [PubMed]  Article 
Target
Name:
Isoform Beta of cGMP-dependent protein kinase 1 [5-676,G306E]
Synonyms:
KGP1_HUMAN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-dependent protein kinase 1 [5-676,G306E] | hPKG 1 beta (aa 5-676)
Type:
Protein
Mol. Mass.:
76225.72
Organism:
Homo sapiens (Human)
Description:
Q13976-2 (1-351) (G306E)
Residue:
672
Sequence:
RDLQYALQEKIEELRQRDALIDELELELDQKDELIQKLQNELDKYRSVIRPATQQAQKQSASTLQGEPRTKRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPSEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPP
  
Inhibitor
Name:
BDBM65501
Synonyms:
8-pCP-cGMP | Cyclic GMP analogs | cGMP
Type:
Small organic molecule
Emp. Form.:
C16H15ClN5O7PS
Mol. Mass.:
487.811
SMILES:
Nc1nc(=O)c2nc(Sc3ccc(Cl)cc3)n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c2[nH]1
Structure:
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