Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM337777
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
71.0±n/a nM
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent  US9751843 Publication Date 9/5/2017 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM337777
Synonyms:
3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1-{4-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]phenyl}-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid | US9751843, 170
Type:
Small organic molecule
Emp. Form.:
C25H22F3N3O6
Mol. Mass.:
517.4539
SMILES:
Cc1c(Cn2c(=O)c(cn(-c3ccc(CCN4CCOC4=O)cc3)c2=O)C(O)=O)cccc1C(F)(F)F
Structure:
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