Target
Chymase
Ligand
BDBM337788
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
18.0±n/a nM
Citation
 Fürstner, CAckerstaff, JStraub, AMeier, HTinel, HZimmermann, KTersteegen, AZubov, DKast, RSchamberger, JSchäfer, M Substituted uracils and use thereof US Patent  US9751843 Publication Date 9/5/2017 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM337788
Synonyms:
1-(3,4-Dimethoxyphenyl)-2,4-dioxo-3-[4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid (racemate) | US9751843, 181
Type:
Small organic molecule
Emp. Form.:
C23H19F3N2O6
Mol. Mass.:
476.402
SMILES:
COc1ccc(cc1OC)-n1cc(C(O)=O)c(=O)n(C2CCc3c2cccc3C(F)(F)F)c1=O
Structure:
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