Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM13942
Substrate
BDBM12679
Meas. Tech.
Enzyme Assay and Determination of the Inhibition Constants
pH
7.5±n/a
Temperature
295.15±n/a K
Ki
1700±n/a nM
Citation
Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. J Mol Biol 307:1451-86 (2001) [PubMed] Article
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
Inhibitor
Name:
BDBM13942
Synonyms:
2-(2-HYDROXY-PHENYL)-1H-INDOLE-5-CARBOXAMIDINE | APC-8328 | {amino[2-(2-hydroxyphenyl)-1H-indol-5-yl]methylidene}azanium
Type:
Small organic molecule
Emp. Form.:
C15H14N3O
Mol. Mass.:
252.2906
SMILES:
NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1ccccc1O