Reaction Details Report a problem with these data
Target
Retinaldehyde-binding protein 1
Ligand
BDBM338912
Substrate
n/a
Meas. Tech.
Isomerase Assay
IC50
<100.0±n/a nM
Citation
 Scott, IL; Kuksa, VA; Gall, A; Orme, MW; Gage, J; Little, Jr., TL; Jiang, Q; Rossiter, LM; McGee, Jr., KF; Kubota, R Styrenyl derivative compounds for treating ophthalmic diseases and disorders US Patent  US10201545 Publication Date 2/12/2019 
Target
Name:
Retinaldehyde-binding protein 1
Synonyms:
CRALBP | Cellular retinaldehyde-binding protein | RLBP1 | RLBP1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36462.25
Organism:
Homo sapiens (Human)
Description:
P12271
Residue:
317
Sequence:
MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETREEAVRELQEMVQAQAASGEELAVAVAERVQEKDSGFFLRFIRARKFNVGRAYELLRGYVNFRLQYPELFDSLSPEAVRCTIEAGYPGVLSSRDKYGRVVMLFNIENWQSQEITFDEILQAYCFILEKLLENEETQINGFCIIENFKGFTMQQAASLRTSDLRKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGDDLSGFYQEIDENILPSDFGGTLPKYDGKAVAEQLFGPQAQAENTAF
  
Inhibitor
Name:
BDBM338912
Synonyms:
(E)-1-(5-(3-amino-1-hydroxypropyl)-2- methoxystyryl)cyclohexanol | US10201545, Compound 120
Type:
Small organic molecule
Emp. Form.:
C18H27NO3
Mol. Mass.:
305.4119
SMILES:
COc1ccc(cc1\C=C\C1(O)CCCCC1)C(O)CCN
Structure:
Search PDB for entries with ligand similarity: